| Pair Name | Vitamin C, Topotecan | ||
| Phytochemical Name | Vitamin C (PubChem CID: 54670067 ) | ||
| Anticancer drug Name | Topotecan (PubChem CID: 60700 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Vitamin C, Topotecan | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Expression | H2AX | hsa3014 |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Synergistic enhancement of topotecan-induced cell death by ascorbic acid in human breast MCF-7 tumor cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic enhancement of topotecan-induced cell death by ascorbic acid in human breast MCF-7 tumor cells. Free Radic Biol Med. 2017 Dec;113:406-412. doi: 10.1016/j.freeradbiomed.2017.10.377 | Click |
